| slovo | definícia |
frameshift
(gcide) | frameshift \frame"shift\, a. (Genetics)
of, pertaining to, or causing a type of mutation consisting
of the insertion or deletion of one or more nucleotides in
the nucleic acid structure of a gene, when the number of base
pairs inserted or deleted is not a multiple of three. If the
addition or deletion occurs in multiples of three, the
unaffected nucleotides in the genome remain in the proper
order ("frame") to be correctly translated into protein; in
such cases of insertions or deletions not causing a frame
shift, a functional though altered protein may be produced by
the organism. Frameshift mutations cause more profound
changes in the composition of the protein resulting from
translation of the mutated gene.
[PJC] |
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