| slovo | definícia |
C17H14O4S
(gcide) | rofecoxib \rofecoxib\ (Chem. & Med.)
A chemical substance (C17H14O4S, molecular weight 314.36)
used in medicine as an analgesic to alleviate pain and
inflammation; it is a synthetic compound, and is marketed by
Merck & Co. under the trade name Vioxx, in tablets giving
dosages of 12.5 or 25 milligrams. It is classed as a
non-steroidal anti-inflammatory drug (NSAID). Chemically, it
is 4-[4-(methylsulfony)phenyl]-3-phenyl-2(5H) furanone. Its
chemical structure contains two phenyl rings and a furanone
ring. It is believed to act by inhibition of prostaglandin
biosynthesis, through inhibition of the enzyme
cyclooxygenase-2 (COX-2); unlike aspirin, it does not
inhibit cyclooxygenase-1.
[PJC] |
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